Limiting dilution comparison of the repertoires of high and low responder MHC-restricted T cells.

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Limiting dilution comparison of the repertoires of high and low responder MHC-restricted T cells

To approach the mechanism that determines Ir gene-controlled high or low responsiveness to whole proteins, such as sperm whale myoglobin (SWMb), we compared the repertoires of high and low responder haplotype-restricted T cells for different myoglobin epitopes by limiting dilution frequency analysis. Poisson analysis was performed using long-term limiting dilution cell lines of (B10.BR [low] X ...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1988

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.167.3.1100